The role of environmental impact in healthcare providers’ choices of inhalers for treatment of asthma and COPD: a discrete choice experiment | BMC Primary Care

Watts N, Amann M, Ayeb-Karlsson S, Belesova K, Bouley T, Boykoff M, et al. The lancet countdown on health and climate change: from 25 years of inaction to a global transformation for public health. Lancet. 2018;391(10120):581–630.
Google Scholar
Lenzen M, Malik A, Li M, Fry J, Weisz H, Pichler PP, et al. The environmental footprint of health care: a global assessment. Lancet Planet Health. 2020;4(7):e271–9.
Google Scholar
Pencheon D, Wight J. Making healthcare and health systems net zero. BMJ. 2020;368:m970.
Google Scholar
Steenmeijer MA, Pieters LI, Warmenhoven N, Huiberts EHW, Stoelinga M, Zijp MC. Het effect van de Nederlandse zorg op het milieu. Bilthoven: Rijksinstituut voor Volksgezondheid en Milieu (RIVM); 2022.
Alessandro M, Francesca L, Shyamali CD, Cecilie S, Joachim H, Bénédicte L, et al. The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories. Eur Respir J. 2021;58(5):2004656.
Google Scholar
Fidler L, Green S, Wintemute K. Pressurized metered-dose inhalers and their impact on climate change. CMAJ. 2022;194(12):E460.
Google Scholar
Pritchard JN. The climate is changing for metered-dose inhalers and action is needed. Drug Des Devel Ther. 2020;14:3043–55.
Google Scholar
Jeswani HK, Azapagic A. Life cycle environmental impacts of inhalers. J Clean Prod. 2019;237: 117733.
Google Scholar
British Thoracic Society. Environment and Lung Health Position Statement. 2020.
SFK. 180.000 mensen gebruiken meerdere typen inhalatoren: Pharmaceutisch Weekblad; 2021. Available from: https://www.pw.nl/vaste-rubrieken/sfk/2021/180-000-mensen-gebruiken-meerdere-typen-inhalatoren#:~:text=Circa%201%2C4%20miljoen%20mensen,en%2014%25%20van%20de%20bevolking.
Ten Have P, van Hal P, Wichers I, Kooistra J, Hagedoorn P, Brakema EA, et al. Turning green: the impact of changing to more eco-friendly respiratory healthcare – a carbon and cost analysis of Dutch prescription data. BMJ Open. 2022;12(6): e055546.
Google Scholar
Hänsel M, Bambach T, Wachtel H. Reduced environmental impact of the reusable Respimat(®) soft mist™ inhaler compared with pressurised metered-dose inhalers. Adv Ther. 2019;36(9):2487–92.
Google Scholar
Ossebaard H, Ten Have P, Van Hal P, Wichers I, Brakema E, De Heer P, et al. Groenere longzorg is mogelijk. Huisarts Wet. 2023;66:10–5. https://doi.org/10.1007/s12445-023-2252-5.
Wichers I, Pieters L. Milieu-impact van inhalatoren in Nederland en wereldwijd. Ned Tijdschr Geneeskd. 2022;166.
Bischoff E, Bouma M, Broekhuizen L, Donkers J, Hallensleben C, De Jong J, et al. NHG Standaard COPD. 2021.
Bottema JW, Bouma M, Broekhuizen L, Chavannes NH, Frankemölle LAM, Hallensleben C, et al. NHG-Standaard Astma bij volwassenen. 2020.
Janson C, Henderson R, Löfdahl M, Hedberg M, Sharma R, Wilkinson AJK. Carbon footprint impact of the choice of inhalers for asthma and COPD. Thorax. 2020;75(1):82–4.
Google Scholar
Groenewegen P, Boerma WGW, Spreeuwenberg P, Seifert B, Schäfer W, Batenburg R, et al. Task shifting from general practitioners to practice assistants and nurses in primary care: a cross-sectional survey in 34 countries. Prim Health Care Res Dev. 2022;23:e60.
Google Scholar
Francetic I, Gibson J, Spooner S, Checkland K, Sutton M. Skill-mix change and outcomes in primary care: longitudinal analysis of general practices in England 2015–2019. Soc Sci Med. 2022;308: 115224.
Google Scholar
Kroneman M, Boerma W, van den Berg M, Groenewegen P, de Jong J, van Ginneken E. Netherlands: health system review. Health Syst Transit. 2016;18(2):1–240.
Google Scholar
Tervonen T, Hawken N, Hanania NA, Martinez FJ, Heidenreich S, Gilbert I. Maintenance inhaler therapy preferences of patients with asthma or chronic obstructive pulmonary disease: a discrete choice experiment. Thorax. 2020;75(9):735–43.
Google Scholar
Bøgelund M, Hagelund L, Asmussen MB. COPD-treating nurses’ preferences for inhaler attributes – a discrete choice experiment. Curr Med Res Opin. 2017;33(1):71–5.
Google Scholar
Chouaid C, Germain N, De Pouvourville G, Aballéa S, Korchagina D, Baldwin M, et al. Patient preference for chronic obstructive pulmonary disease (COPD) treatment inhalers: a discrete choice experiment in France. Curr Med Res Opin. 2019;35(5):785–92.
Google Scholar
Collacott H, Zhang D, Heidenreich S, Tervonen T. A systematic and critical review of discrete choice experiments in asthma and chronic obstructive pulmonary disease. Patient. 2022;15(1):55–68.
Google Scholar
Hawken N, Torvinen S, Neine ME, Amri I, Toumi M, Aballéa S, et al. Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment. BMC Pulm Med. 2017;17(1):99.
Google Scholar
Kawata AK, Kleinman L, Harding G, Ramachandran S. Evaluation of patient preference and willingness to pay for attributes of maintenance medication for chronic obstructive pulmonary disease (COPD). Patient. 2014;7(4):413–26.
Google Scholar
Lewis HB, Schroeder M, Gunsoy NB, Janssen EM, Llewellyn S, Doll HA, et al. Evaluating patient preferences of maintenance therapy for the treatment of chronic obstructive pulmonary disease: a discrete choice experiment in the UK, USA and Germany. Int J Chron Obstruct Pulmon Dis. 2020;15:595–604.
Google Scholar
Laba TL, Reddel HK, Zwar NJ, Marks GB, Roughead E, Flynn A, et al. Does a patient-directed financial incentive affect patient choices about controller medicines for asthma? A discrete choice experiment and financial impact analysis. Pharmacoeconomics. 2019;37(2):227–38.
Google Scholar
Soekhai V, de Bekker-Grob EW, Ellis AR, Vass CM. Discrete choice experiments in health economics: past, present and future. Pharmacoeconomics. 2019;37(2):201–26.
Google Scholar
Groenewoud S, Van Exel NJA, Bobinac A, Berg M, Huijsman R, Stolk EA. What influences patients’ decisions when choosing a health care provider? Measuring preferences of patients with knee arthrosis, chronic depression, or Alzheimer’s disease, using discrete choice experiments. Health Serv Res. 2015;50(6):1941–72.
Google Scholar
Veldkamp R, Schackmann L, Horsselenberg M, Vervloet M, van Dijk L, Hek K. Inhalatiemedicatie en overwegingen van milieu-impact in de eerste lijn: een kwantitatieve analyse van toedieningsvormen en een kwalitatieve studie naar motivatie voor het meewegen van milieu-impact van geneesmiddelen door patiënten en zorgverleners. Utrecht: Nivel; 2022.
Lancsar E, Louviere J. Conducting discrete choice experiments to inform healthcare decision making: a user’s guide. Pharmacoeconomics. 2008;26(8):661–77.
Google Scholar
Zorginstituut Nederland. Farmacotherapeutisch KompasU bevindt zich hier:Farmacotherapeutisch Kompas. 2024. Available from: https://www.farmacotherapeutischkompas.nl/.
Reed Johnson F, Lancsar E, Marshall D, Kilambi V, Mühlbacher A, Regier DA, et al. Constructing experimental designs for discrete-choice experiments: report of the ISPOR conjoint analysis experimental design good research practices task force. Value Health. 2013;16(1):3–13.
Google Scholar
Survey Engine Software. Available from: https://surveyengine.com/.
Jaynes J, Wong W-K, Xu H. Using blocked fractional factorial designs to construct discrete choice experiments for healthcare studies. Stat Med. 2016;35(15):2543–60.
Google Scholar
Janssen EM, Marshall DA, Hauber AB, Bridges JFP. Improving the quality of discrete-choice experiments in health: how can we assess validity and reliability? Expert Rev Pharmacoecon Outcomes Res. 2017;17(6):531–42.
Google Scholar
Johnson FR, Yang JC, Reed SD. The internal validity of discrete choice experiment data: a testing tool for quantitative assessments. Value Health. 2019;22(2):157–60.
Google Scholar
Ajzen I. The theory of planned behavior. Organ Behav Hum Decis Process. 1991;50(2):179–211.
Google Scholar
De Groene Huisarts. Available from: https://wp.degroenehuisarts.nl/.
Bridges JFP, Hauber AB, Marshall D, Lloyd A, Prosser LA, Regier DA, et al. Conjoint analysis applications in health—a checklist: a report of the ISPOR good research practices for conjoint analysis task force. Value Health. 2011;14(4):403–13.
Google Scholar
Nivel Primary Care Database. Available from: https://www.nivel.nl/en/our-databases-and-panels/nivel-primary-care-database.
Lancsar E, Louviere J. Deleting “irrational” responses from discrete choice experiments: a case of investigating or imposing preferences? Health Econ. 2006;15(8):797–811.
Google Scholar
Hess S, Palma D. Apollo: a flexible, powerful and customisable freeware package for choice model estimation and application. J Choice Model. 2019;32: 100170.
Google Scholar
Lough G, Bosnic-Anticevich S, Roche N, Usmani OS. Patient and provider perspectives driving inhaler choice: optimizing sustainable health care. Chest. 2024;166(5):934–7.
Google Scholar
Aboueid S, Beyene M, Nur T. Barriers and enablers to implementing environmentally sustainable practices in healthcare: a scoping review and proposed roadmap. Healthc Manage Forum. 2023;36(6):405–13.
Google Scholar
Oosterveld B, Dubbeldeman E, Brakema E, Broese J, Chavannes N, van der Kleij R. Klimaatvriendelijker voorschrijven en gebruik van inhalatiemedicatie. Leids Universitair Medisch Centrum; 2023.
Verhaar A, Knottnerus B, Brabers A, Wagner C. Deel zorggebruikers zegt klimaatimpact te willen meewegen bij zorgkeuze. Utrecht: Nivel; 2022.
Onderzoek Verduurzaming van zorg: Patiëntenfederatie Nederland; 2024. Available from: https://www.patientenfederatie.nl/dit-doen-wij/onderzoeken/onderzoek-verduurzaming-van-zorg.
Ramerman L, Hek K, van der Cramer Welle C, Simons-Winters E, Middelweerd A, Lambooij A, et al. Incentivizing appropriate prescribing in primary care: development and first results of an electronic health record-based pay-for-performance scheme. Health Policy. 2022;126(10):1010–7.
Google Scholar
Levy ML, Bateman ED, Allan K, Bacharier LB, Bonini M, Boulet L-P, et al. Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective. Lancet. 2023;402(10406):1012–6.
Google Scholar
Batenburg R, Flinterman L, Vis E, van Schaaijk A, Kenens RJ, Duijkers B. Cijfers uit de Nivel-registratie van huisartsen en huisartsenpraktijken: een actualisering voor de periode 2020–2022. Utrecht: Nivel; 2022.
de Bekker-Grob EW, Swait JD, Kassahun HT, Bliemer MCJ, Jonker MF, Veldwijk J, et al. Are healthcare choices predictable? The impact of discrete choice experiment designs and models. Value Health. 2019;22(9):1050–62.
Google Scholar
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